精神分裂症同胞对的错误加工的神经及遗传机制的研究

As is well known that the incidence rate of schizophrenia in healthy siblings of schizophrenia patients is ten times higher than that of the general population. And the impairment in their social, learning and working function is also appear in familial aggregation, especially the hypersensitivity resulted in the abnormal processing of negative events, which is considered to be the cause of social cognitive dysfunction. The hypersensitivity of certain events is called salience, which is supposed to be a possible pathopsychological mechanism. Yet, neither the mechanism nor the genetic basis of hypersensitivity caused by abnormal erroneous processing is still unknown. By using schizophrenia patients, their healthy siblings and healthy people as research subjects, this project aims to explore the mechanism and hereditary basis of gene-environment interaction in schizophrenia in an overall level through studying the abnormality of neural connection during the cognition task of negative events sensitivity. It is expected that this project would provide grounds for the early diagnosis and intervention of schizophrenia

众所周知，精神分裂症患者的健康同胞的发病率比普通人群高10倍，社交、学习和工作能力下降也存在家族聚集性，特别是对负性事件的错误加工而形成的过度敏感被认为是社会认知功能障碍的原因。对某些事件的过度敏感被称为“突显”，被认为是精神分裂症的可能的病理心理机制，但目前还不清楚异常错误加工导致的精神过度敏感的可能的神经机制，以及与遗传基因的关系。本项目以精神分裂症、患者的健康同胞以及健康对照为研究对象，探究负性事件敏感性的认知任务时脑网络连接的异常以及与相关基因的关系，从整体水平上探索精神分裂症的基因-环境交互作用的发病机制，为其早期诊断和干预提供科学依据。

精神分裂症患者的健康同胞的发病率比普通人群高近10倍，社交、学习和工作能力下降也存在家族聚集性，特别是对负性事件的错误加工而形成的过度敏感被认为是社会认知功能障碍的原因。对某些事件的过度敏感被称为“突显”，被认为是精神分裂症的可能的病理心理机制，但目前还不清楚异常错误加工导致的精神过度敏感的可能的神经机制，以及与遗传基因的关系。本项目以精神分裂症、患者的健康同胞以及健康对照为研究对象，共采集了156名精神分裂症患者（随访44名）、100名正常对照，49名精神分裂症同胞的核磁共振数据、基因数据、认知功能评估数据，以探究负性事件敏感性的认知任务时脑网络连接的异常以及与相关基因的关系，从整体水平上探索了精神分裂症的基因-环境交互作用的发病机制，为其早期诊断和干预提供科学依据。