具有聚集诱导发光性能的阳离子型红光/近红外光材料的设计、合成及应用研究

Recently, red/NIR aggregation-induced emission (AIE) materials have received much attention in the field of fluorescent imaging and detection due to their special emission behavior and high solid state emission efficiency. But the present red/NIR AIE materials exist some drawbacks such as lack of structure diversity, complicate synthetic route and difficult to modify. This project aim to exploit novel cationic red/NIR AIE materials based on intramolecular charge transfer (ICT) process, using heterocyclic quaternary ammonium salts as electronic acceptor and AIE group tetraphenylethene (TPE) with its derivatives as electronic donor. Besides AIE feature, this kind of AIE material possesses other advantages such as high molar absorption coefficient, large Stokes shift, simple synthetic route and easy to modify. Based on above features, this project will turn to develop the applications of these materials in the fields of fluorescent sensor and specific bio-imaging. By the rational design and functionalization, we will develop the novel “light-up” red/NIR AIE fluorescent sensor for analyte which can be carried out in aqueous and film state. In addition, we will develop red/NIR AIE dyes and bioprobes for the specific organelles and cancer cell or tissue imaging. The development of this project will broaden the composition of AIE materials and their application fields.

具有聚集诱导发光(AIE)效应的红光/近红外光材料由于具有特殊的发光行为和高的固态发光效率，近年来受到荧光标记与检测等研究领域的极大关注。但目前该类材料存在种类少、合成复杂及难修饰等缺点。本项目拟采用氮杂环季铵盐作为电子受体，具有AIE效应的四苯乙烯及其衍生物作为电子給体，通过分子内电荷转移过程的构建，制备新颖的阳离子型AIE红光尤其是近红外发光材料。此类材料除具有AIE特性以外，还具有摩尔吸光系数高、斯托克斯位移大、合成简単及易修饰等特点。基于以上优点，本项目将开展它们在荧光传感和荧光靶向标记领域的应用研究。通过合理的分子设计与修饰，开发有别于传统AIE机制的“点亮”型荧光传感器，实现其在水相及薄膜中对被测物的检测；开发AIE红光/近红外光染料分子及生物探针，并实现其对特定细胞器及癌细胞/组织的靶向标记功能。本项目的实施将有效拓宽AIE材料的组成结构及其应用领域。

具有聚集诱导发光(AIE)效应的红光材料由于具有特殊的发光行为和高的固态发光效率，近年来受到荧光标记与检测等研究领域的极大关注。但目前该类材料存在种类少、合成复杂及难修饰等缺点。为了解决这一关键问题，本项目以氮杂环季铵盐作为电子受体，具有AIE效应的四苯乙烯及其衍生物作为电子給体，通过分子内电荷转移过程的构建，制备了一系列新颖的阳离子型AIE红光材料，系统研究了该类材料的分子结构与发光特性之间的关系。成功将所制备的相关材料应用于离子的高灵敏检测、线粒体的靶向成像以及线粒膜电位的原位监测。在上述研究基础上，我们还对新型AIE体系以及多功能的固态发光体系进行了有效探索。成功发展了一类基于二氰基乙烯基的新型AIE材料和一类基于联二萘酚的手性AIE材料，揭示了取代基对其发光行为的影响。发展了基于香豆素的多功能固态发光材料，系统研究了其多重刺激响应性质。相关结果为新型AIE材料的构建和应用提供了良好的基础。项目执行期间，发表SCI论文7篇，获授权专利3项，培养硕士研究生3人。