基于经济环保型低维纳米结构材料的有机环境激素的检测

Environment endocrines disrupt endocrine functions and are linked to adverse effects on the reproductive system in wildlife and human. Therefore, the determination of these chemicals in environment has become a very urgent task, and thus the development of convenient and efficient analytical methods has become an important subject in environmental analysis. In addition, with the development of conceptions of “green chemistry” and “environment-friendly”, analytical methods were not only evaluated from the sensitivity, precision, reproducibility, analysis speed and operating procedures, etc., but also to consider the economic costs, operators' safety and environmental pollution, and to avoid producing more pollution in the analysis process. In this study, new analytical methods was established according to the urgency of environmental estrogen determination, the key issues in analytical methodology, and the principles of green analytical chemistry. To quickly and efficiently separate and concentrate these trace environmental endocrines, new nano-materials with low dimensional structures were synthesized or modified, and used as sorbents for solid phase extraction (SPE) of environmental estrogens from environmental samples due to their large specific surface area, good dispersity, strong adsorption and convenient elution. The separated and concentrated samples were determined subsequently by GC-MS and LC-MS. Moreover, new SPE technologies were developed and the conditions were optimized by response surface method (RSM). The implementation of this study for the development of analytical methods of environmental endocrine and human health is of great significance.

有机环境激素对人类和野生动物的内分泌系统产生严重不良影响。因此，它们在环境中的含量监测已成为十分紧迫的任务，发展相应的方便、高效的样品处理技术已成为环境分析中的重要课题。随着“绿色化学”和“经济环保”等理念的发展，对分析方法的评价，不只从灵敏度、精密度、重现性、分析速度和操作程序等方面来考虑，而且要考虑经济成本、操作者的安全和环境的污染，避免在分析过程中产生更多的污染。本项目针对环境激素监测的紧迫性、检测方法学中的关键问题以及绿色化学原则，合成新型经济环保型低维纳米结构材料，并研究其作用机理；发展固相萃取（SPE）新技术，减少操作步骤，降低溶剂消耗和挥发；通过响应曲面法（RSM）进行条件优化，实现环境样品中环境激素的快速分离和富集，建立固相萃取-气相色谱-质谱(GC-MS)/液相色谱-质谱(LC-MS)检测新方法。本项目的实施对于环境激素检测方法学的发展和人类健康具有重要意义。

有机环境激素对人类和野生动物的内分泌系统产生严重不良影响。因此，它们在环境中的含量监测已成为十分紧迫的任务，发展相应的方便、高效的样品处理技术已成为环境分析中的重要课题。随着“绿色化学”和“经济环保”等理念的发展，对分析方法的评价，不只从灵敏度、精密度、重现性、分析速度和操作程序等方面来考虑，而且要考虑经济成本、操作者的安全和环境的污染，避免在分析过程中产生更多的污染。本项目针对环境激素监测的紧迫性、检测方法学中的关键问题以及绿色化学原则，合成了新型经济环保型低维纳米结构材料，并研究其作用机理；发展新型样品处理技术，减少操作步骤，降低溶剂消耗和挥发；通过响应曲面法（RSM）进行条件优化，实现环境样品中环境激素的快速分离和富集，建立固相萃取-气相色谱-质谱(GC-MS)/液相色谱-质谱(LC-MS)/实时直接分析质谱(DART-MS)的检测新方法。本项目的实施对于环境激素检测方法学的发展和人类健康具有重要意义。