一种新的人端粒相关锌指蛋白基因（TASL30）的鉴定及表达研究

In this study, the full length of TASL30 cDNA has been sequenced and analysed to be a novel telomere-associated zinc finger gene. Northern blot analysis shows that TASL30 mRNA is expressed in early embryos but the expression level decreases during in older embryos with no mRNA detectable in all adult organs analyzed. To investigate the expression of TASL30 protein, an antibody against TASL30 protein has been prepared. Then Western blot analysis shows that the TASL30 protein is expressed in fetal liver but not in other fetal organs and the expression level of TASL30 is correlated with the hepatic development. All these suggests that TASL30 may involve in the development of fetal liver in early human fetuses.

TASL30基因是本室从早期人胚dDNA文库中首次发现的与人端粒DNA和锌指蛋白基因同源的新颉１狙芯客ü云淙蛄胁舛ā⒔峁狗治觥⑷旧宥ㄎ患捌浔泶镅芯浚幼己头胨椒治鯰ASL30在人早期胚胎和50种牧民组织细胞内的表达情况，研究结果将首次提出并证实肆Ｏ喙谼NA能够转录有翻译功能的mRNA，并且首次发现位于染色体端部的锌指基因，填补国内外空白。