抽动秽语综合征儿童伴外周铁缺乏的多模态磁共振影像研究

Tourette syndrome (TS) is a common movement disorder in children. It has high prevalence, many comorbidities and affects the quality of children's life in negative way. The definite pathophysiology of TS is still unclear. Our previous clinical studies found that part of TS children who had peripheral iron deficiency suffered severer tic symptoms, and oral iron supplementation can improve their symptoms of tic and comorbidities. So it is significant to study the neuro-pathology of TS with peripheral iron deficiency. Combined with the use of multi-modal neuroimaging techniques, including susceptibility weighted imaging and resting-state functional magnetic resonance imaging, we aimed to find the neuro-marker of TS children with peripheral iron deficiency and the neuroimaging alterations after oral iron supplementation. The research can provide ideas to explore the relationship with peripheral iron deficiency in TS, aiding in its treatment.

抽动秽语综合征是儿童常见的运动障碍疾病，其患病率高，共患病多，严重影响了患儿的生活质量，但目前病因尚不明确。我们前期的研究发现部分抽动秽语综合征儿童伴有外周铁含量缺乏，其抽动症状更严重，且口服补铁治疗可改善其抽动症状及共患病症状，研究抽动秽语综合征伴外周铁缺乏的脑神经机制具有重要意义。本研究将基于磁化率加权成像、静息态功能磁共振等多模态磁共振技术，观察抽动秽语综合征伴外周铁缺乏的脑影像学变化，以及补铁治疗后对其脑影像学指标的影响，探寻抽动秽语综合征和外周铁缺乏的关系，为抽动秽语综合征的药物治疗选择提供客观依据。

抽动秽语综合征是儿童常见的运动障碍疾病，其患病率高，共患病多，严重影响了患儿的生活质量，但目前病因尚不明确。我们前期的研究发现部分抽动秽语综合征儿童伴有外周铁含量缺乏，其抽动症状更严重，且口服补铁治疗可改善其抽动症状及共患病症状，研究抽动秽语综合征伴外周铁缺乏的脑神经机制具有重要意义。该项目基本按照研究计划，运用多模态磁共振技术，结合临床症状评定量表及血清铁蛋白等实验室指标对TS儿童进行横向研究。结果显示：TS儿童在认知控制功能网络的频段特异性异常与其行为失控有关，TS-铁缺乏儿童在多处脑区有低频振幅和功能连接的异常改变，提示了TS发病相关的脑网络或影像学指标，为铁缺乏在TS的发病机制提供理论基础。