cathepsin B/stefin A表达失衡对喉癌侵袭转移的影响及cathepsin B 作为喉癌治疗性靶标的研究
基本信息
结项摘要
本研究利用我室前期工作组织芯片和基因芯片技术的结果分析了喉癌组织和其相邻正常粘膜组织的差异基因的表达及蛋白的差异表达，为进一步探索喉癌的发病机制，寻找喉癌特异的分子标志物提供了理论基础。本课题借助siRNA和基因转染方法分别促使基因cathepsin B表达保持沉默、cystatin A过表达，分析cathepsin B和cystatin A之间平衡破坏对喉癌细胞侵袭、转移的影响，以cathepsin B 的抑制剂CA-074Me验证cathepsin B 可能成为喉癌治疗的靶标。并进一步通过体外、体内筛选cathepsin B的高效分子抑制剂，为阻断喉癌细胞侵袭、转移提供有效的分子阻遏物。
项目摘要
项目成果
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数据更新时间：2023-05-31
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