一个潜在的、防治骨质破坏的药物靶点的新发现
基本信息
结项摘要
课题申请者近期应用嵌合体(chimera)构建技术和基因转染技术，在RANK( receptor activator of nuclear factor kappaB)蛋白中找到了一个8个氨基酸大小的片段，发现它对破骨细胞(osteoclast,OC)分化起决定性的作用。该研究成果在国内外尚未见文献报道。本课题拟进一步应用嵌合体构建技术、定点突变技术、破骨细胞分化实验、骨重吸收实验和Western Blot等方法，试图在这个片段中找到RANK调节OCs分化真正起作用的氨基酸，并详细研究其功能和激活的信号传导途径。这一研究将有助于揭示多发性骨髓瘤、肾性骨病、老年性骨质疏松、激素引起的骨质疏松、类风湿性关节炎等骨损害的发病机制，更重要的是还可为将来开发治疗骨损害的药物提供新的特异性靶点。
项目摘要
项目成果
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数据更新时间：2023-05-31
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