不同腧穴配伍对功能性便秘受试者效应差异及其中枢机制的研究

Acupoint,as the component of acupuncture, is clinical basis. Generally, the acupoint formula is applied clinically. Previous studies demonstrated that acupuncturing acupoints which locate at back and abdomen could increase or decrease gastroentestinal motility. Therefore, whether the effect of these formulas can induce 1+1>1 or 1+1<1 remains to be answered. Here we will recuit the health people and the patients with functional constipation and detect different formula which comprised of Tianshu, Dachangshu and Shangjuxu can produce different effects-sychonalization and antagonism and the mechanisms underlying the above effects, and thus provide evidence for the application of correct acupoint formula. This novel idea is extreme important for the elucidating acupoint theory and its clinical application.

腧穴作为针灸学的重要内容之一，是临床遣方用针的基础。临床用穴多是多穴配合应用。已有实验研究也表明，分别针刺背部腧穴与腹部腧穴对大鼠胃肠运动表现出增强和抑制两方面的作用。因此，这些位于不同部位的腧穴在应用中是否是1加1大于1或1加1小于1在现在临床和实验研究中鲜有涉及。 本研究以健康受试者和功能性便秘病人为研究对象，以临床疗效观察结合肛门直肠压力检测并结合静息态功能性磁共振成像技术，研究天枢、上巨虚和大肠俞三穴配伍后的效应差异，以揭示不同配穴的拮抗和协同效应及产生机制，为阐明腧穴配伍的科学性提供科学证据。不仅切入点新，而且，对于合理诠释和应用腧穴理论具有重要意义。