基于复杂网络的磁刺激穴位对亚健康失眠的作用效应研究

As the pace of life continues to increase, more and more people are in the subhealthy state. Insomnia is the most common symptoms of subhealthy state. And it has seriously affected people’s quality of life. Magnetic stimulation is an effective, painless and non-invasive technique. And it is also easy to duplicate and operate. It has distinctive effects on nervous system function regulation, disease treatment and rehabilitation therapy. Acupuncture point is the point where acupuncture stimulation is used to regulate nervous system. In this project, using a transcranial magnetic stimulation (TMS) system low-frequency repetitive pulse magnetic stimulation would be given to the specific acupuncuture points used in clinic to treat insomnia. And EEG data would be recorded and analyzed using a 128-channel EEG analysis system. Multi-channel EEG signals would be recorded before, during and after magnetic stimulaiton.And EEG synchronization would be analyzed. Brain functioinal network characteristics of subhealthy insomnia would be studied to determine whether magnetic stimulation at acupuncture point would effect subhealthy insomnia or not. This project involves in Chinese medicine, electromagnetic technique, information technology and neuroscience. It is a multidisciplinary cross research and has very important academic and clinical application values.

随着生活节奏的加快，越来越多的人处于亚健康状态。失眠是亚健康状态最为常见的症候，严重影响了人们的生活质量。磁刺激以其有效、无痛、无损伤、无需接触电极、易于重复和操作简便等优点，在人体神经功能调控、疾病治疗与康复理疗等方面具有独特的成效。穴位是中医针灸调控神经系统由体表刺激到体内的切入点，本项目针对亚健康失眠者，利用经颅磁刺激（TMS）系统和128导脑电（EEG）分析仪，选取对失眠有典型临床作用的穴位点进行重复脉冲磁刺激，提取磁刺激前、中、后的多导脑电信号，通过多通道脑电信号同步性分析，构建亚健康失眠者不同状态下的脑功能网络，探讨磁刺激穴位对亚健康失眠的作用效应。本项目涉及中医学、电磁技术、信息技术、神经科学等诸多学科交叉研究，具有重要的学术和临床应用价值。

随着生活节奏的加快，越来越多的人处于亚健康失眠状态，严重影响了人们的生活质量。磁刺激与电刺激在分子水平的机制相似，然而磁刺激具有更多的优点，如无痛、无接触等。穴位是中医针灸调控神经系统由体表刺激到体内的切入点。本项目针对亚健康失眠者，选取对失眠有典型临床作用的穴位点进行了重复脉冲磁刺激，提取了刺激前、中、后的多导脑电信号，基于复杂网络理论,构建了亚健康失眠状态下的脑功能网络，分析了磁刺激穴位对亚健康失眠的作用效应。本项目已完成各项研究内容，发表学术论文11篇，其中SCI检索期刊论文2篇，EI期刊检索论文5篇，EI检索会议论文2篇，中文核心期刊论文2篇，培养研究生毕业2名，研究生在读2名，参加国内、外相关学术会议12人次。研究结果发现磁刺激穴位可增强亚健康失眠者的脑功能网络连接，改善亚健康失眠者睡眠质量，为临床失眠疾病的治疗提供了新方法和新思路。