心钠素前体分子内调控及在老年高血压发病中的意义

This study elucidated the role of interaction and the molar ratio change of two different fragments , kaliuretic peptide(KP) and atrial natriuretic peptide (ANP) , from atrial natriuretic factors prohormone in elderly essential hypertension. The results showed that comparing with the control group , the plasma molar ratio of KP/ANP in elder essential hypertension(EH) and elderly spontaneously hypertensive rat(SHR) were decreased significantly. Moreover, some kind of medicine such as aritholol ,imidapril, amlodipine and losartan could increased the plasma molar ratio of KP/ANP in elder EH and elderly SHR .Hyperisotonic natrium muriaticum accelerate the secretion of KP and ANP. However, the secretary reaction for two peptides are much different. KP trend to be fast and short. By contrast, the release of ANP are slow and long. .The degradation of KP in the kidney of SHR and control group Wistar-kyoto(WKY) rats are no significant different. On opposition , the catabolism of ANP show a significant different between SHR and WKY rats. Northern blot analysis revealed that ANP gene expression occurs in SHR and WKY rats myocardial cell .ANP prohormone messenger RNA gene expression in SHR was significantly lower than in WKY when myocardial cell be treated by exogenous KP and ANP. The results suggest that interamolecular regulation of atrial natriuretic factors prohormone maybe play a role in pathogenesis of elderly essential hypertension.

利钾尿肽（KP）与心钠素（ANP）是来源于同一前体的不同片段。两者生理作用相似，但前咔坑诤笳摺１狙芯坎捎孟赴镅Ш头肿由镅侄危鄄炝秸呒涞南嗷プ饔枚曰謇颉⒗萍笆嬲叛茏饔玫母谋浜投孕难芡绲鹘谙低车挠跋欤云谟眯哪扑厍疤宸肿幽诘骼砺郏骼夏暝⑿愿哐狗⒉〉姆肿踊坪土俅灿靡┨峁┬碌睦砺垡谰荨