喉鳞癌中人类乳头瘤病毒HPV对癌基因C-myc激活的研究
基本信息
结项摘要
采用Dotblot杂交以HPV11.16为探针对喉鳞癌，癌前病变研究结果：喉癌总感染率66.66%。HPV16与喉癌关系密切，其感染率分别占喉癌，癌前病变及正常组织的38.09%，25%及0%。PCR技术HPVE1区设计引物研究发现喉鳞癌，乳头瘤，角化症，颈转移淋巴结及正常喉组织中的阳性率分别为68%，75%，50%，80%及16.66%。癌及癌前病变中E1阳性率与正常组织相比差异显著P<0.05。PCR参入法标记HPV探针Southern blot分析发现HPV-DNA在喉癌中有三种方式存在即整合，游离及整合兼游离。Southern blot研究发现C-myc在喉癌中处于以扩增为特征的激活状态。其中23例高倍扩增（10-39倍）专利号是HPV阳性者占21例，而癌前病变及正常喉组织均无扩增表现。说明HPV与癌基因激活有关，与喉癌的发生有重要关系。
项目摘要
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数据更新时间：2023-05-31
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