ICOS-Fc诱导特异性移植免疫耐受的实验研究
基本信息
结项摘要
避免器官移植术后免疫排斥反应的发生是四十余年来科学家们梦寐以求的目标，诱导受体特异性的免疫耐受是解决上述问题的理想途径。移植免疫排斥反应的发生过程中必须依赖于共刺激分子的作用，新近发现的ICOS具有促进T细胞分化并发挥效应的主要共刺激分子，ICOS主要表达于活化的CD4＋T细胞、CD8＋T细胞（包括CD28＋CD8＋T细胞）以及记忆型T细胞，具有促进T细胞分化和分泌多种细胞因子并发挥效应，在二次免疫应答及免疫记忆中起着重要作用。本研究以小鼠皮片移植为试验模型，设计采用小剂量供体抗原分次刺激受体，同时以重组的ICOS-Fc融合蛋白阻断ICOS/B7h共刺激分子的相互作用，诱导对移植抗原的特异性免疫耐受，为进一步研究临床移植免疫耐受提供新的理论依据和途径。
项目摘要
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数据更新时间：2023-05-31
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